Vera A. Khokhlova

Doctor of Science
Database information: 
Areas of Research Activity: 
Acoustic holography
General topics of nonlinear wave physics
High-intensity focused ultrasound (HIFU) in therapy and noninvasive surgery
Industrial ultrasound applications
Kidney stone fragmentation by ultrasound waves
Metrology of ultrasound sources and their fields
Nonlinear problems in aeroacoustics
Numerical modeling in acoustics
Ultrasound imaging methods in medicine
Education: 
  • 2012 – D.Sc. in Acoustics from M.V. Lomonosov Moscow State University (MSU)
  • 1991 – PhD in Acoustics from M.V. Lomonosov Moscow State University
  • 1979 – 1986 – MS Program (diploma with honors), Department of Acoustics, Physics Faculty of MSU
Professional position: 
  • 1996 – present – Associate Professor, Dept. of Acoustics, Physics Faculty of MSU; 
  • 1991 – 1996 – Research Scientist, Dept. of Acoustics, Physics Faculty of MSU;
  • 1990 – 1991 – Junior Research Scientist; Dept. of Acoustics, Physics Faculty of MSU;
Honors/Awards: 
  • 2022 – Rayleigh-Helmholtz Interdisciplinary Silver Medal in Biomedical Acoustics and Physical Acoustics for contributions to the application of nonlinear acoustics to medical ultrasound
  • 2022 - present – Associate Editor of  the International Journal of Hyperthermia
  • 2015 - present – Elected Member of the Board of the Russian Acoustical Society (Member since 2001)
  • 2013 - 2022 – Associate Editor of  the journal IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
  • 2012 - 2015 – Elected Member of the Executive Council of the Acoustical Society of America (ASA)
  • 2004 - 2008, 2011 - 2014 – Elected Member of the Board of the International Society for Therapeutic Ultrasound (Member since 2001)
  • 2009 - present – Member of the “Physical Ultrasound” division of the Scientific Council on Acoustics of the Russian Academy of Sciences
  • 2008 - present – Fellow of the Acoustical Society of America (Member since 1993)
  • 2008 - 2012 – Member of the Committee on Standards of ASA
  • 2008 - present – Member of the International Organizing Committee of the International Symposium on Nonlinear Acoustics 
  • 2005 - present – Member of the Committee on International Research and Education of ASA
Show additional information Show publications

Publications

2023

  1. R.P. Williams, J.C. Simon, V.A. Khokhlova, O.A. Sapozhnikov, and T.D. Khokhlova
    "The histotripsy spectrum: differences and similarities in techniques and instrumentation"

    International Journal of Hyperthermia,

    40
    1
    1-19, DOI: 10.1080/02656736.2023.2233720
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  2. P.B. Rosnitskiy, S.A. Tsysar, M.M. Karzova, S.V. Buravkov, P.G. Malkov, N.V. Danilova, E.M. Ponomarchuk, O.A. Sapozhnikov, T.D. Khokhlova, G.R. Schade, A.D. Maxwell, Y.N. Wang, A.V. Kadrev, A.L. Chernyaev, D.A. Okhobotov, A.A. Kamalov, and V.A. Khokhlova
    "Pilot ex vivo study on non-thermal ablation of human prostate adenocarcinoma tissue using boiling histotripsy"

    Ultrasonics,

    133
    107029
    1-8, DOI: 10.1016/j.ultras.2023.107029
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  3. E.M. Ponomarchuk, P.V. Yuldashev, D.A. Nikolaev, S.A. Tsysar, A.A. Mironova, and V.A. Khokhlova
    "Nonlinear ultrasound fields generated by an annular array with electronic and geometric adjustment of its focusing angle"

    Acoustical Physics,

    69
    4
    459–470, DOI: 10.1134/S1063771023600560
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  4. V.A. Khokhlova, P.B. Rosnitskiy, S.A. Tsysar, S.V. Buravkov, E.M. Ponomarchuk, O.A. Sapozhnikov, M.M. Karzova, T.D. Khokhlova, A.D. Maxwell, Y.N. Wang, A.V. Kadrev, A.L. Chernyaev, V.P. Chernikov, D.A. Okhobotov, A.A. Kamalov, and G.R. Schade
    "Initial assessment of boiling histotripsy for mechanical ablation of ex vivo human prostate tissue"

    Ultrasound in Medicine and Biology,

    49
    1
    62–71, DOI: 10.1016/j.ultrasmedbio.2022.07.014
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  5. G.P. Thomas, T.D. Khokhlova, O.A. Sapozhnikov, and V.A. Khokhlova
    "Enhancement of boiling histotripsy by steering the focus axially during the pulse delivery"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control,

    70
    8
    DOI: 10.1109/TUFFC.2023.3286759
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  6. R.P. Williams, M.M. Karzova, P.V. Yuldashev, A.Z. Kaloev, F.A. Nartov, V.A. Khokhlova, B.W. Cunitz, K.P. Morrison, and T.D. Khokhlova
    "Dual-mode 1-D linear ultrasound array for image-guided drug delivery enhancement without ultrasound contrast agents"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control,

    70
    7
    693–707, DOI: 10.1109/tuffc.2023.3268603
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  7. M.M. Karzova, W. Kreider, A. Partanen, T.D. Khokhlova, O.A. Sapozhnikov, P.V. Yuldashev, and V.A. Khokhlova
    "Comparative characterization of nonlinear ultrasound fields generated by Sonalleve V1 and V2 MR-HIFU systems"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control,

    70
    6
    521–537, DOI: 10.1109/TUFFC.2023.3261420
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  8. S.A. Asfandiyarov, P.B. Rosnitskiy, S.A. Tsysar, P.V. Yuldashev, V.A. Khokhlova, V.E. Sinitsyn, E.A. Mershina, and O.A. Sapozhnikov
    "Estimation of the thickness profile of a human skull phantom by ultrasound methods using a two-dimensional array"

    Acoustical Physics,

    69
    1
    112–118, DOI: 10.1134/S106377102270004X
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  9. P.A. Pestova, M.M. Karzova, P.V. Yuldashev, and V.A. Khokhlova
    "The use of focused ultrasound beams with shocks to suppress diffusion effects in volumetric thermal ablation of biological tissue"

    Acoustical Physics,

    69
    4
    448–458, DOI: 10.1134/S1063771023600468
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  10. A.V. Tyurina, P.V. Yuldashev, I.B. Esipov, and V.A. Khokhlova
    "Quasilinear approximation for modeling difference-frequency acoustic wave in a diffracting pump-wave beam"

    Acoustical Physics,

    69
    1
    30–39, DOI: 10.1134/S1063771022700014
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2022

  1. G.P. Thomas, T.D. Khokhlova, O.A. Sapozhnikov, Y.N. Wang, S.I. Totten, and V.A. Khokhlova
    "In vivo aberration correction for transcutaneous hifu therapy using a multielement array"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control,

    69
    10
    2955–2964, DOI: 10.1109/tuffc.2022.3200309
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  2. A.T. Peek, P.L. Thomas Gilles, D.F. Leotta, P.V. Yuldashev, V.A. Khokhlova, and T.D. Khokhlova
    "Robust and durable aberrative and absorptive phantom for therapeutic ultrasound applications"

    Journal of the Acoustical Society of America,

    151
    5
    3007–3018, DOI: 10.1121/10.0010369
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  3. D.D. Chupova, P.B. Rosnitskiy, L.R. Gavrilov, and V.A. Khokhlova
    "Compensation for aberrations of focused ultrasound beams in transcranial sonications of brain at different depths"

    Acoustical Physics,

    68
    1
    1–10, DOI: 10.1134/S1063771022010018
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  4. A.Z. Kaloev, D.A. Nikolaev, V.A. Khokhlova, S.A. Tsysar, and O.A. Sapozhnikov
    "Spatial correction of an acoustic hologram for reconstructing surface vibrations of an axially symmetric ultrasound transducer"

    Acoustical Physics,

    68
    1
    71–82, DOI: 10.1134/S1063771022010043
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  5. A.V. Tyurina, P.V. Yuldashev, I.B. Esipov, and V.A. Khokhlova
    "Spectral modeling of difference-frequency generation in the case of two-frequency interaction of ultrasound waves"

    Acoustical Physics,

    68
    2
    130–137, DOI: 10.1134/S1063771022020105
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  6. M. Song, G.P.L. Thomas, V.A. Khokhlova, O.A. Sapozhnikov, M.R. Bailey, A.D. Maxwell, P.V. Yuldashev, and T.D. Khokhlova
    "Quantitative assessment of boiling histotripsy progression based on color doppler measurements"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control,

    69
    12
    3255–3269, DOI: 10.1109/TUFFC.2022.3212266
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  7. E.M. Ponomarchuk, C. Hunter, M. Song, V.A. Khokhlova, O.A. Sapozhnikov, P.V. Yuldashev, and T.D. Khokhlova
    "Mechanical damage thresholds for hematomas near gas-containing bodies in pulsed HIFU fields"

    Physics in Medicine and Biology,

    67
    21
    1–18, DOI: 10.1088/1361-6560/ac96c7
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  8. E.O. Konnova, V.A. Khokhlova, and P.V. Yuldashev
    "The use of graphic accelerators in simulation of nonlinear ultrasonic beams with shock fronts on the basis of the Westerwelt equation"

    Acoustical Physics,

    68
    6
    529–536, DOI: 10.1134/S1063771022060161
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2021

  1. P.V. Yuldashev, M.M. Karzova, W. Kreider, P.B. Rosnitskiy, O.A. Sapozhnikov and V.A.Khokhlova.
    "“HIFU beam”: a simulator for predicting axially symmetric nonlinear acoustic fields generated by focused transducers in a layered medium"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Sept. 2021,

    68
    9
    2837–2852. DOI: 10.1109/TUFFC.2021.3074611
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  2. G.P.L. Thomas, T.D. Khokhlova and V.A. Khokhlova.
    "Partial respiratory motion compensation for abdominal extracorporeal boiling histotripsy treatments with a robotic arm"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Sept. 2021

    68
    9
    2861–2870. DOI: 10.1109/TUFFC.2021.3075938
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  3. M.M. Karzova, P.V. Yuldashev, V.A. Khokhlova, F.A. Nartov, K.P. Morrison and T.D. Khokhlova
    "Dual-use transducer for ultrasound imaging and pulsed focused ultrasound (pFUS) therapy"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Sept. 2021

    68
    9
    2930–2941. DOI: 10.1109/TUFFC.2021.3070528
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  4. C.R. Bawiec, P.B. Rosnitskiy, A.T. Peek, A.D. Maxwell, W. Kreider, G.R. ter Haar, O.A. Sapozhnikov, V.A. Khokhlova, T.D Khokhlova.
    "Inertial cavitation behaviors induced by nonlinear focused ultrasound pulses"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Sept. 2021

    68
    9
    2884–2895. DOI: 10.1109/TUFFC.2021.3073347
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  5. Z. Xu, V.A. Khokhlova, K.A. Wear, J.-F. Aubry, and T.A. Bigelow.
    "Introduction to the Special Issue on Histotripsy: Approaches, Mechanisms, Hardware, and Applications"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Sept. 2021

    68
    9
    2834–2836. DOI: 10.1109/TUFFC.2021.3102092
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  6. E.M. Ponomarchuk, P.B. Rosnitskiy, T.D. Khokhlova, S.V. Buravkov, S.A. Tsysar, M.M. Karzova, K.D. Tumanova, A.V. Kunturova, Y.N. Wang, O.A. Sapozhnikov, P.E. Trakhtman, N.N. Starostin, and V.A. Khokhlova
    "Ultrastructural analysis of volumetric histotripsy bio-effects in large human hematomas"

    Ultrasound in Medicine and Biology

    47
    9
    2608–2621. DOI: 10.1016/j.ultrasmedbio.2021.05.002
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  7. C. R. Bawiec, T. D. Khokhlova, O. A. Sapozhnikov, P.B. Rosnitskiy, B.W. Cunitz, M.A. Ghanem, C. Hunter, W. Kreider, G.R. Schade, P.V. Yuldashev, V.A. Khokhlova
    "A prototype therapy system for boiling histotripsy in abdominal targets based on a 256 element spiral array"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, May 2021

    68
    5
    1496-1510. DOI: 10.1109/TUFFC.2020.3036580
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  8. D.A. Nikolaev, S.A. Tsysar, V.A. Khokhlova, W. Kreider, and O.A. Sapozhnikov
    "Holographic extraction of plane waves from an ultrasound beam for acoustic characterization of an absorbing layer of finite dimensions"

    Journal of the Acoustical Society of America

    149
    1
    386–404
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  9. P.V. Yuldashev, M.M. Karzova, V.A. Khokhlova, and Ph Blanc-Benon
    "Numerical simulation of a nonlinear parabolic equation for analyzing the perceived loudness statistics of sonic boom wave after propagation through atmospheric turbulent layer"

    Acoustical Physics

    67
    1
    26-37
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  10. P.A. Pestova, M.M. Karzova, P.V. Yuldashev, W. Kreider, and V.A. Khokhlova
    "Impact of treatment trajectory on temperature field uniformity in biological tissue irradiated by ultrasound pulses with shocks"

    Acoustical Physics

    67
    3
    250–258
  11. E.O. Konnova, P.V. Yuldashev, V.A. Khokhlova
    "Using graphics accelerators in modeling nonlinear ultrasonic beams on the basis of the Westervelt equation"

    Bulletin of the Russian Academy of Sciences: Physics

    85
    6
    632 – 636, DOI: 10.3103/S1062873821060125
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  12. A.S. Bobina, P.B. Rosnitskiy, T.D. Khokhlova, P.V. Yuldashev, V.A. Khokhlova
    "Effect of abdominal wall inhomogeneities on the focusing of an ultrasonic beam at different positions of the transducer"

    Bulletin of the Russian Academy of Sciences: Physics

    85
    6
    675 – 680, DOI: 10.3103/S1062873821060058
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2020

  1. M.A. Ghanem, A.D. Maxwell, Y.-N. Wang, B.W. Cunitz, V.A. Khokhlova, O.A. Sapozhnikov, and M.R. Bailey
    "Noninvasive acoustic manipulation of objects in a living body"

    Proceedings of the National Academy of Sciences

    Jul 2020
    202001779
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  2. G.P.L. Thomas, T.D. Khokhlova, C.R. Bawiec, A.T. Peek, O.A. Sapozhnikov, M.O’Donnell, and V.A. Khokhlova
    "Phase-aberration correction for HIFU therapy using a multi-element array and backscattering of nonlinear pulses"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

    Oct. 14
    in print
  3. T.D. Khokhlova, J.C. Kucewicz, E.M. Ponomarchuk, C. Hunter, M. Bruce, V.A. Khokhlova, T.J. Matula, W. Monsky
    "Effect of stiffness of large extravascular hematomas on their susceptibility to boiling histotripsy liquefaction in vitro"

    Ultrasound in Medicine & Biology

    46
    8
    2007-2016
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  4. T.J. Matula, Y.-N. Wang, T.D. Khokhlova, D.F. Leotta, J. Kucewicz, A.A. Brayman, M. Bruce, A.D. Maxwell, B.E. Macconaghy, G. Thomas, V.P. Chernikov, S.V. Buravkov, V.A. Khokhlova, K. Richmond, K.T. Chan, W.L. Monsky
    "Treating porcine abscesses with histotripsy: a pilot study"

    Ultrasound in Medicine & Biology

    47
    3
    603-619
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  5. A.T. Peek, C. Hunter, W. Kreider, T.D. Khokhlova, P.B. Rosnitskiy, P.V. Yuldashev, O.A. Sapozhnikov, V.A. Khokhlova
    "Bilayer aberration-inducing gel phantom for high intensity focused ultrasound applications"

    The Journal of the Acoustical Society of America

    148
    6
    3569–3580
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  6. P.B. Rosnitskiy, O.A. Sapozhnikov, L.R. Gavrilov, and V.A. Khokhlova
    "Designing fully populated phased arrays for noninvasive ultrasound surgery with controlled degree of irregularity in the arrangement of elements"

    Acoustical Physics

    4
    4
    352–361
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2019

  1. T.D. Khokhlova, G.R. Schade, Y.-N.Wang, S.V. Buravkov, V.P. Chernikov, J.C. Simon, F. Starr, A.D. Maxwell, M.R. Bailey, W. Kreider, V.A. Khokhlova
    "Pilot in vivo studies on transcutaneous boiling histotripsy in porcine liver and kidney"

    Scientific Reports

    9
    20176
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  2. M.A. Ghanem, A.D. Maxwell, O.A. Sapozhnikov, V.A. Khokhlova, and M.R. Bailey
    "Quantification of acoustic radiation forces on solid objects in fluid"

    Physical Review Applied

    12
    044076 (1–13)
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  3. T.J. Dubinsky, T.D. Khokhlova, V.A. Khokhlova, G.A. Schade
    "Histotripsy: the next generation of high‐intensity focused ultrasound for focal prostate cancer therapy"

    J. Ultrasound. Med.

    39
    6
    1057-1067
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  4. O.A. Sapozhnikov, V.A. Khokhlova, R.O. Cleveland, P. Blanc-Benon, M.F. Hamilton
    "Nonlinear Acoustics Today"

    Acoustics Today

    15
    3
    55–64
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  5. P.B. Rosnitskiy, P.V. Yuldashev, O.A. Sapozhnikov, L.R. Gavrilov, V.A. Khokhlova
    "Simulation of nonlinear trans-skull focusing and formation of shocks in brain using a fully populated ultrasound array with aberration correction"

    The Journal of the Acoustical Society of America

    146
    3
    1786–1798
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  6. M.M. Karzova, T. Lechat, S. Ollivier, D. Dragna, P.V. Yuldashev, V.A. Khokhlova, P. Blanc-Benon
    "Irregular reflection of spark-generated shock pulses from a rigid surface: Mach-Zehnder interferometry measurements in air"

    The Journal of the Acoustical Society of America

    145
    1
    26-35
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  7. M.M. Karzova, T. Lechat, S. Ollivier, D. Dragna, P. Yuldashev, V.A. Khokhlova, P. Blanc-Benon
    "Effect of surface roughness on nonlinear reflection of weak shock waves"

    The Journal of the Acoustical Society of America

    146
    5
    438-443
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  8. Y.S. Andriyakhina, M.M. Karzova, P.V. Yuldashev, V.A. Khokhlova
    "Accelerated thermal ablation of biological tissue volumes using HIFU beams with shock fronts"

    Acoustical Physics

    65
    2
    141-150
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  9. A.V. Nikolaeva, M.M. Karzova, S.A. Tsysar, V.A. Khokhlova, O.A. Sapozhnikov
    "Simulating and measuring the acoustic radiation force of a focused ultrasonic beam on elastic spheres in water"

    Bulletin of the Russian Academy of Sciences: Physics

    83
    1
    77-81
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2018

  1. D.A. Sukhoruchkin, P.V. Yuldashev, S.A. Tsysar, V.A. Khokhlova, V.D. Svet , O.A. Sapozhnikov
    "Use of pulse-echo ultrasound imaging in transcranial diagnostics of brain structures"

    Bulletin of the Russian Academy of Sciences: Physics

    82
    5
    507–511
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  2. A. A. Brayman, B. E. Macconaghy, Y. N. Wang, K.T. Chan, W.L. Monsky , V.P. Chernikov , S.V. Buravkov , V.A. Khokhlova , T.J. Matula
    "Inactivation of planktonic escherichia coli by focused 1-MHz ultrasound pulses with shocks: efficacy and kinetics upon volume scale-up "

    Ultrasound in Medicine and Biology

    44
    9
    1996–2008
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  3. M. A. Ghanem, A. D. Maxwell, W. Kreider, B.W. Cunitz, V.A. Khokhlova, O.A. Sapozhnikov, M.R. Bailey
    "Field characterization and compensation of vibrational non-uniformity for a 256-element focused ultrasound phased array "

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

    65
    9
    1618–1630
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  4. P. B. Rosnitskiy, B. A. Vysokanov, L. R. Gavrilov, O.A. Sapozhnikov, V.A. Khokhlova
    "Method for designing multielement fully populated random phased arrays for ultrasound surgery applications "

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

    65
    4
    630–637
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  5. P.V. Yuldashev, I.S. Mezdrokhin , V.A. Khokhlova
    "Wide-angle parabolic approximation for modeling high-intensity fields from strongly focused ultrasound transducers "

    Acoustical Physics

    64
    3
    309-319
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  6. T. Khokhlova, P. Rosnitskiy, C. Hunter, A. Maxwell, W. Kreider, G. ter Haar, M. Costa, O. Sapozhnikov, V. Khokhlova
    "Dependence of inertial cavitation induced by high intensity focused ultrasound on transducer f-number and nonlinear waveform distortion "

    Journal of the Acoustical Society of America

    144
    3
    1160–1169
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  7. Y.-N. Wang, T.D. Khokhlova, S.V. Buravkov, V.P. Chernikov, W. Kreider, A. Partanen, N. Farr, A.D. Maxwell, G.R. Schade, V.A. Khokhlova
    "Mechanical decellularization of tissue volumes using boiling histotripsy"

    Phys. Med. Biol.

    63
    23
    235023

2017

  1. P.B. Rosnitskiy, P.V. Yuldashev, O.A. Sapozhnikov, A. Maxwell, W. Kreider, M.R. Bailey, V.A. Khokhlova
    "Design of HIFU transducers for generating specified nonlinear ultrasound fields"

    IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

    64
    2
    374 – 390
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  2. M.M. Karzova, P.V. Yuldashev, O.A. Sapozhnikov, V.A. Khokhlova, B.W. Cunitz, W. Kreider, M.R. Bailey
    "Shock formation and nonlinear saturation effects in the ultrasound field of a diagnostic curvilinear probe"

    The Journal of the Acoustical Society of America

    141
    4
    2327-2337
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  3. Khokhlova T.D., Haider Y.A., Maxwell A.D., Kreider W., Bailey M.R., Khokhlova V.A.
    "Dependence of boiling histotripsy treatment efficiency on HIFU frequency and focal pressure levels"

    Ultrasound in Medicine and Biology

    43
    9
    1975-1985
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  4. Maxwell A.D., Yuldashev P.V., Kreider W., Khokhlova T.D., Schade G.R., Hall T.L., Sapozhnikov O.A., Bailey M.R., Khokhlova V.A.
    "A prototype therapy system for transcutaneous application of boiling histotripsy"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

    64
    10
    1542-1557
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  5. Rosnitskiy P., Gavrilov L., Yuldashev P., Sapozhnikov O., Khokhlova V.
    "On the Possibility of Using Multi-Element Phased Arrays for Shock-Wave Action on Deep Brain Structures"

    Acoustical Physics

    63
    5
    531-540
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  6. Karzova M.M., Yuldashev P.V., Rosnitskiy P.B., Khokhlova V.A.
    "Numerical Approaches to Simulating Nonlinear Ultrasound Fields Generated by Diagnostic-Type Transducers"

    Bulletin of the Russian Academy of Sciences: Physics

    81
    8
    927-931
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2016

  1. P.B. Rosnitskiy, P.V. Yuldashev, B.A. Vysokanov, and V.A. Khokhlova
    "Setting boundary conditions to the Khokhlov–Zabolotskaya equation for modeling ultrasound fields generated by strongly focused transducers"

    Acoustical Physics

    62
    2
    151–159
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  2. P.B. Rosnitskiy, P.V. Yuldashev, O.A. Sapozhnikov, A. Maxwell, W. Kreider, M.R. Bailey, V.A. Khokhlova
    "Design of HIFU transducers to generate specific nonlinear ultrasound fields"

    Physics Procedia

    87
    132 – 138
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  3. C. Hunter, O.A. Sapozhnikov, A.D Maxwell, V.A. Khokhlova, Y.N. Wang, B. MacConaghy, W. Kreider
    "An ultrasonic caliper device for measuring acoustic nonlinearity"

    Physics Procedia

    87
    93 – 98
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2015

  1. S.A. Ilyin, P.V. Yuldashev, V.A. Khokhlova, L.R. Gavrilov, P.B. Rosnitskiy, and O.A. Sapozhnikov
    "Analytical Method for Evaluating the Quality of Acoustic Fields Radiated by a Multielement Therapeutic Array with Electronic Focus Steering"

    Acoustical Physics, 2015

    61
    1
    52-59
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  2. J. C. Simon, O. A. Sapozhnikov, V. A. Khokhlova, L. A. Crum and M. R. Bailey
    "Ultrasonic atomization of liquids in drop-chain acoustic fountains"

    J. Fluid Mech. (2015)

    766
    129-146
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  3. Vera A. Khokhlova, J. Brian Fowlkes, William W. Roberts, George R. Schade, Zhen Xu, Tatiana D. Khokhlova,Timothy L. Hall, Adam D. Maxwell, Yak-Nam Wang, & Charles A. Cain
    "Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications"

    Int J Hyperthermia, 2015

    31
    2
    145-162
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  4. P. B. Rosnitskiy, P. V. Yuldashev, and V. A. Khokhlova
    "Effect of the Angular Aperture of Medical Ultrasound Transducers on the Parameters of Nonlinear Ultrasound Field with Shocks at the Focus"

    Acoustical Physics, 2015

    61
    3
    301-307
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  5. J.C. Simon, O.A. Sapozhnikov, Y.N. Wang, V.A. Khokhlova, L.A. Crum, M.R. Bailey
    "Investigation into the mechanisms of tissue atomization by high intensity focused ultrasound"

    Ultrasound in Medicine & Biology

    41
    5
    1372-1385
    PDF icon download
  6. M.M. Karzova, P.V. Yuldashev, V.A. Khokhlova, S. Ollivier, E. Salze, Ph. Blanc-Benon
    "Characterization of spark-generated N-waves in air using an optical schlieren method"

    The Journal of the Acoustical Society of America

    137
    6
    3244-3252
    PDF icon download
  7. P.V. Yuldashev, M.M. Karzova, V.A. Khokhlova, S. Ollivier, Ph. Blanc-Benon
    "Mach-Zehnder interferometry method for acoustic shock wave measurements in air and broadband calibration of microphones"

    The Journal of the Acoustical Society of America

    137
    6
    3314-3324
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  8. M.M. Karzova, V.A. Khokhlova, E. Salze, S. Ollivier, Ph. Blanc-Benon
    "Mach stem formation in reflection and focusing of weak shock acoustic pulses"

    The Journal of the Acoustical Society of America

    137
    EL436
    436–442
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  9. S.A. Ilyin, L.R. Gavrilov, V.A. Khokhlova
    "Application of ultrasound phased arrays with different number of elements for irradiation of tissue behind the ribs"

    Memoirs of the Faculty of Physics

    5
    145342
  10. V.A. Khokhlova, J.B. Fowlkes, W.W. Roberts, G.R. Schade, Z. Xu, T.D. Khokhlova, T.L. Hall, A.D. Maxwell, Y.N. Wang, C.A. Cain
    "Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications"

    Int. J. Hyperthermia

    31
    2
    145-162
    PDF icon download
  11. J.C. Simon, O.A. Sapozhnikov, Y.N. Wang, V.A. Khokhlova, L.A. Crum, M.R. Bailey
    "Investigation into the mechanisms of tissue atomization by high intensity focused ultrasound"

    Ultrasound in Medicine & Biology

    41
    5
    1372-1385
    PDF icon download
  12. О.A. Sapozhnikov, S.A. Tsysar, V.A. Khokhlova, W. Kreider
    "Acoustic holography as a metrological tool for characterizing medical ultrasound sources and fields"

    The Journal of the Acoustical Society of America

    138
    3
    1515-1532
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  13. A.N. Rybyanets, A.A. Naumenko, O.A. Sapozhnikov, V.A. Khokhlova
    "New methods and transducer designs for ultrasonic diagnostics and therapy"

    Physics procedia

    70
    1152-1156
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  14. Gavrilov L.R., Sapozhnikov O.A., Khokhlova V.A.
    "Spiral arrangement of elements of two-dimensional ultrasonic therapeutic arrays as a way of increasing the intensity at the focus"

    Bulletin of the Russian Academy of Sciences. Physics

    79
    10
    1232–1237
    PDF icon download
  15. M. M. Karzova , P. V. Yuldashev, V. A. Khokhlova, S. Ollivier, Ph. Blanc-Benon
    "Application of a Mach–Zehnder interferometer to the observation of mach stem formation when a shock wave is reflected from a rigid surface"

    Bulletin of the Russian Academy of Sciences: Physics.

    79
    10
    1293-1295
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2014

  1. T. D. Khokhlova, Y.-N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova
    "Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model"

    PNAS

    111
    22
    8161-8166
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  2. E. G. Lobanova, S. V. Lobanov, and V. A. Khokhlova
    "Counterpropagation of Waves with Shock Fronts in a Nonlinear TissueLike Medium"

    Acoustical Physics, 2014

    60
    4
    387–397
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  3. E. Salze, P.V. Yuldashev, S. Ollivier, V.A. Khokhlova, P. Blanc-Benon
    "Laboratory-scale experiment to study nonlinear N-wave distortion by thermal turbulence"

    The Journal of the Acoustical Society of America

    136
    2
    556-566
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  4. V. A. Khokhlova, Y.-N. Wang, S.V. Buravkov, A.D. Maxwell, T.D. Khokhlova, D.W. Lin, O.A. Sapozhnikov, M.R. Bailey, G.R. Schade
    "Histological analysis of mechanical lesions induced by high intensity focused ultrasound in ex-vivo human and porcine kidneys"

    Memoirs of the Faculty of Physics

    5
    145343
  5. P.B. Rosnitskiy, P.V. Yuldashev, V.A. Khokhlova
    "Determination of the parameters of a high power ultrasound transducer to provide certain shock amplitude at the focus"

    Memoirs of the Faculty of Physics

    5
    145314
  6. P.V. Yuldashev, A. Maxwell, W. Kreider, O.A. Sapozhnikov, M. Bailey, L. Crum, V.A. Khokhlova
    "Measurement and modeling of acoustic field of a therapeutic multielement transducer in a wide range of acoustic intensities up to appearance of saturation effect in the focus"

    Memoirs of the Faculty of Physics

    5
    145346

2013

  1. W. Kreider, P. V. Yuldashev, O. A. Sapozhnikov, N. Farr, A. Partanen, M. R. Bailey, and V. A. Khokhlova
    "Characterization of a Multi-Element Clinical HIFU System Using Acoustic Holography and Nonlinear Modeling"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

    60
    8
    1683-1698
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  2. V. A. Khokhlova, S. M. Shmeleva, L. R. Gavrilov, E. Martin, N. Sadhoo, and A. Shaw
    "Infrared mapping of ultrasound fields generated by medical transducers: Feasibility of determining absolute intensity levels"

    J. Acoust. Soc. Am.

    134
    2
    1586–1597
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  3. Y.-N. Wang, T.D. Khokhlova, M.R. Bailey, J.-H. Hwang, V.A. Khokhlova
    "Histological and biochemical analysis of mechanical and thermal bioeffects in boiling histotripsy lesions induced by high intensity focused ultrasound"

    Ultrasound in Medicine & Biology

    39
    3
    424-438
  4. P.V. Yuldashev, S.M. Shmeleva, S.A. Ilyin, O.A. Sapozhnikov, L.R. Gavrilov, V.A. Khokhlova
    "The role of acoustic nonlinearity in tissue heating behind a rib cage using high intensity focused ultrasound phased array"

    Phys. Med. Biol.

    58
    8
    2537-2559
  5. V.A. Khokhlova, L.A. Crum
    "Introduction to the special issue on therapeutic ultrasound"

    J. Acoust. Soc. Am.

    134
    2
    1441
  6. C. Perez, H. Chen, T.J. Matula, M.S. Karzova, V.A. Khokhlova
    "Acoustic field characterization of the Duolith: Measurements and modeling of a clinical shockwave therapy device"

    J. Acoust. Soc. Am.

    134
    2
    1663-1674
  7. V.A. Khokhlova, Y.-N. Wang, S.V. Buravkov, A.D. Maxwell, T.D. Khokhlova, D.W. Lin, O.A. Sapozhnikov, M.R. Bailey, G.R. Schade
    "Histological analysis of mechanical lesions induced by high intensity focused ultrasound in ex-vivo human and porcine kidneys"

    Memoirs of the Faculty of Physics

    39
    3
    424-438

2012

  1. M.M. Karzova, M.V. Averiyanov, O.A. Sapozhnikov, and V.A. Khokhlova
    "Mechanisms for saturation of nonlinear pulsed and periodic signals in focused acoustic beams"

    Acoust. Phys.

    58
    1
    81–89
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  2. J.C. Simon, O.A. Sapozhnikov, V.A. Khokhlova, Y.-N. Wang, L.A. Crum, and M.R. Bailey
    "Ultrasonic atomization of tissue and its role in tissue fractionation by high intensity focused ultrasound"

    Phys. Med. Biol.

    57
    23
    8061-8078
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  3. A. Maxwell, O. Sapozhnikov, M. Bailey, L. Crum, Z. Xu, B. Fowlkes, C. Cain, V. Khokhlova.
    "Disintegration of tissue using high intensity focused ultrasound: Two approaches that utilize shock waves"

    Acoustics Today

    8
    4
    24-36

2011

  1. P.V. Yuldashev, V.A. Khokhlova
    "Simulation of three-dimensional nonlinear fields of ultrasound therapeutic arrays"

    Acoust. Phys.

    57
    3
    334-343
  2. S.A. Ilyin, S.M. Bobkova, V.A. Khokhlova, L.R. Gavrilov
    "Simulation of thermal lesions in biological tissues irradiated by high-intensity focused ultrasound through the rib cage"

    Physics of Wave Phenomena

    19
    1
    62-67
  3. M.V. Averiyanov, Ph. Blanc-Benon, R.O. Cleveland, V.A. Khokhlova
    "Nonlinear and diffraction effects in propagation of N-waves in randomly inhomogeneous moving media"

    J. Acoust. Soc. Am.

    129
    4
    1760-1772
  4. T.D. Khokhlova, M.S. Canney, V.A. Khokhlova, O.A. Sapozhnikov, L.A. Crum, M. R. Bailey
    "Controlled tissue emulsification produced by high intensity focused ultrasound shock waves and millisecond boiling"

    J. Acoust. Soc. Am.

    130
    5
    3498-3510
  5. M. Averiyanov, S. Ollivier, V. Khokhlova, and Ph. Blanc-Benon
    "Nonlinear acoustic N-wave random focusing in fully developed turbulence: laboratory scale experiment"

    J. Acoust. Soc. Am.

    130
    6
    3595-3607
  6. P. V. Yuldashev and V. A. Khokhlova
    "Simulation of three dimensional nonlinear fields of ultrasound therapeutic arrays"

    Acoustical Physics

    57
    3
    334–343
    PDF icon download

2010

  1. P.V. Yuldashev, N.A. Bryseva, M.V. Averiyanov, Ph. Blanc_Benon, and V.A. Khokhlova
    "Statistical properties of nonlinear diffracting N-wave behind a random phase screen"

    Acoust. Phys.

    56
    2
    158-167
  2. M. Canney, V. Khokhlova, O. Bessonova, M. Bailey, L. Crum
    "Shock-induced heating and millisecond boiling in gels and tissue due to high intensity focused ultrasound"

    Ultrasound in Medicine & Biology

    36
    2
    250-267
  3. S. Bobkova, L. Gavrilov, V. Khokhlova, A. Shaw, and J. Hand
    "Focusing of high intensity ultrasound through the rib cage using a therapeutic random phased array"

    Ultrasound in Medicine & Biology

    36
    6
    888-906
  4. O.V. Bessonova, V.A. Khokhlova, M.S. Canney, M.R. Bailey, and L.A. Crum
    "A derating method for therapeutic applications of high intensity focused ultrasound"

    Acoust. Phys.

    56
    3
    376–385
  5. P. V. Yuldashev, L. M. Krutyanskiі, V. A. Khokhlova, A. P. Brysev, and F. V. Bunkin
    "Distortion of the field of a focused finite_amplitude ultrasonic beam behind the random phase layer"

    Acoust. Phys.

    56
    4
    467–474
  6. V.A. Khokhlova, S.M. Bobkova, L.R. Gavrilov
    "Focus splitting associated with propagation of focused ultrasound through the rib cage"

    Acoust. Phys.

    56
    5
    665–674
  7. P. Yuldashev, S. Ollivier, M. Averiyanov, O. Sapozhnikov, V.Khokhlova, Ph. Blanc-Benon
    "Nonlinear propagation of spark-generated N-waves in air: Modeling and measurements using acoustical and optical methods"

    J. Acoust. Soc. Am.

    128
    6
    3321-3333
  8. L. Gavrilov, V. Khokhlova, S. Bobkova, A. Shaw, and J. Hand
    "Feasibility of noninvasive ultrasound surgery behind the rib cage"

    Medical Physics

    3
    53–64

2009

  1. O.V. Bessonova, V.A. Khokhlova
    "Spatial structure of high intensity focused ultrasound beams of various geometry"

    Physics of Wave Phenomena

    17
    1
    45-49
  2. T.D. Khokhlova, M.S. Canney, D. Lee, K. Marro, V.A. Khokhlova, M.R. Bailey
    "Magnetic resonance imaging of boiling induced by high intensity focused ultrasound"

    J. Acoust. Soc. Am.

    125
    5
    2420-2431
  3. O.V. Bessonova, V.A. Khokhlova, M.R. Bailey, M.S. Canney, and L.A. Crum
    "Focusing of high power ultrasound beams and limiting values of shock wave parameters"

    Acoust. Phys.

    55
    4-5
    463–473
  4. S.M. Bobkova, S.A. Tsysar’, V.A. Khokhlova, and V.G. Andreev
    "Diffraction effects accompanying focused ultrasonic pulse propagation in a medium with a thermal inhomogeneity"

    Acoust. Phys.

    55
    4-5
    474–481

2008

  1. P.V. Yuldashev, M.V. Averiyanov, V.A. Khokhlova, S. Ollivier, Ph. Blanc-Benon
    "Nonlinear spherically divergent shock waves propagating in a relaxing medium"

    Acoust. Phys.

    54
    1
    32–41
  2. M.S. Canney, M.R. Bailey, L.A. Crum, V.A. Khokhlova, and O.A. Sapozhnikov
    "Acoustic characterization of high intensity focused ultrasound fields: A combined measurement and modeling approach"

    J. Acoust. Soc. Am.

    124
    4
    2406-2420

2006

  1. V.A. Khokhlova, M.R. Bailey, J.A. Reed, B.W. Cunitz, P.J. Kaczkowski, and L.A. Crum
    "Effects of nonlinear propagation, cavitation, and boiling in lesion formation by high intensity focused ultrasound in a gel phantom"

    J. Acoust. Soc. Am.

    119
    3
    1834 - 1848
  2. V.G.Andreev, V.A.Vedernikov, A.V.Morozov, V.A.Khokhlova
    "Monitoring of temperature evolution within the focal zone of ultrasound transducer"

    Acoust. Phys.

    52
    2
    119 - 124
  3. V.A. Khokhlova, A.E. Ponomarev, M.A. Averkiou, L.A. Crum
    "Nonlinear pulsed ultrasound beams radiated by rectangular focused diagnostic transducers"

    Acoust. Phys.

    52
    4
    481–489
  4. M.V. Averianov, V.A. Khokhlova, R.O. Cleveland, O.A. Sapozhnikov, Ph. Blanc-Benon
    "Parabolic equation for nonlinear acoustic wave propagation in inhomogeneous moving media"

    Acoust. Phys.

    52
    6
    725-735
  5. C. Lafon, V.A. Khokhlova, P.J. Kaczkowski, M.R. Bailey, O.A. Sapozhnikov, and L.A. Crum
    "Use of a bovine eye lens for observation of HIFU-induced lesions in real-time"

    Ultrasound in Med. and Biol.

    32
    11
    1731-1741

2004

  1. E. A. Filonenko, L. R. Gavrilov, V. A. Khokhlova and J. W. Hand
    "Heating of biological tissues by two-dimensional phased arrays with random and regular element distribution"

    Acoust. Phys.

    50
    2
    222-231
  2. O.A. Sapozhnikov, V.A. Khokhlova, and D.Cathignol
    "Nonlinear waveform distortion and shock formation in the near field of a continuous wave piston source"

    J. Acoust. Soc. Am.

    115
    5(1)
    1982-1987
  3. M.S. Basova and V.A. Khokhlova
    "Effect of frequency-dependent absorption on propagation of nonlinear acoustic wave with shocks"

    Physics of Wave Phenomena

    12
    3
    126-132

2003

  1. M.R. Bailey, V.A. Khokhlova, O.A. Sapozhnikov, S.G. Kargl, and L.A. Crum
    "Physical mechanisms of the therapeutic effect of ultrasound"

    Acoust. Phys.

    49
    4
    369-388

2002

  1. O.V. Sapozhnikov, V.A. Khokhlova, M.R. Bailey, J.C. Williams, J.A. McAteer, R.O. Cleveland, and L.A. Crum
    "Effect of overpressure and pulse repetition frequency on cavitation in shock wave lithotripsy"

    J. Acoust. Soc. Am.

    112
    3(1)
    1183 - 1195

2001

  1. M.R. Bailey, L.N. Couret, O.A. Sapozhnikov, V.A. Khokhlova, G. ter Haar, S. Vaezy, X. Shi, R. Martin,, L.A. Crum
    "Use of overpressure to assess the role of bubbles in focused ultrasound lesion shape in vitro"

    Ultrasound in Med. and Biol.

    27
    5
    695 –708
  2. V.A. Khokhlova, R. Souchon, J. Tavakkoli, O.A. Sapozhnikov, and D. Cathignol
    "Numerical modeling of finite amplitude sound beams: Shock formation in the nearfield of a cw plane piston source"

    J. Acoust. Soc. Am.

    110
    1
    95-108
  3. E.A. Filonenko, V.A. Khokhlova
    "Effect of acoustic nonlinearity on heating of biological tissue induced by high intensity focused ultrasound"

    Acoust. Phys.

    47
    4
    468-475

2000

  1. V.A. Khokhlova, E.A. Filonenko
    "Thermal phenomena at focusing a powerful ultrasonic beam in a two-layer (water – biological tissue) medium"

    Bulletin of the Russian Academy of Sciences, Physics

    64
    12
    1854-1858
  2. V.A. Khokhlova, O.A. Sapozhnikov, S.S. Kashcheeva, P. Lotton, V.E. Gusev, S. Job, and M. Bruneau
    "Effects of nonlinear saturation for acoustic waves propagating in a medium with frequency dependent gain"

    Bulletin of the Russian Academy of Sciences, Physics

    64
    12
    1850-1853
  3. A.A. Slavnov, V.A. Khokhlova
    "Numerical modeling of nonlinear waves with shocks in a waveform and waveform derivative"

    Mosc. Univ. Phys. Bull. , ser. 3, Physics and Astronomy

    1
    28-31
  4. F.P. Curra, P.D. Mourad, V.A. Khokhlova and L.A. Crum
    "Numerical simulations of heating patterns and tissue temperature response due to high-intensity focused ultrasound"

    IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

    47
    4
    1077-1089
  5. S.S. Kashcheeva, O.A. Sapozhnikov, V.A. Khokhlova, M.A. Averkiou, and L.A. Crum
    "Nonlinear distortion and attenuation of intense acoustic waves in lossy media obeying a frequency power law"

    Acoustical Physics

    46
    2
    170-177

1999

  1. V.G. Andreev, Yu.A. Pishchal’nikov, O.A. Sapozhnikov, V.A. Khokhlova, and R.O. Cleveland
    "Diagnostics of a relaxing medium by an acoustic pulse with shock front."

    Acoustical Physics

    45
    1
    8-13
  2. S.V. Gor’kova, S. Kargl, and V.A. Khokhlova
    "Nonlinear and diffraction effects in acoustic beams of cylindrical symmetry"

    Acoustical Physics

    45
    5
    615-621
  3. E.A. Filonenko V.A. Khokhlova
    "Modeling of thermal processes in biological tissue induced by focused ultrasound"

    Mosc. Univ. Phys. Bull., ser. 3, Physics and Astronomy

    29-31

1998

  1. S.S. Kasheeva and V.A. Khokhlova
    "Nonlinear Evolution of Single Shock Pulse in Medium with Power Frequency Law of Absorption"

    Proc. of Academy of Sciences, ser. Physics

    62
    12
    2375-2378

1997

  1. M.F. Hamilton, V.A. Khokhlova, and O.V. Rudenko
    "New method of calculation of paraxial region of intense acoustic beams"

    Acoustical Physics

    43
    1
    39-44
  2. M.F. Hamilton, V.A. Khokhlova, and O.V. Rudenko
    "Analytical method for describing the paraxial region of finite amplitude sound beams"

    J. Acoust. Soc. Am.

    101
    3
    1298-1308

1996

  1. Yu.A. Pishal’nikov, O.A. Sapozhnikov and V.A. Khokhlova
    "A modification of the spectral description of nonlinear acoustic waves with discontinuities"

    Acoustical Physics

    42
    3
    362-367
  2. A.N. Dubrovskii, V.A. Khokhlova, and O.V. Rudenko
    "Fluctuation characteristics of a sonic boom after passing through randomly inhomogeneous layer"

    Acoustical Physics

    42
    5
    550-554

1994

  1. O.V. Rudenko and V.A. Khokhlova
    "Statistics of Sawtooth Acoustic Waves with Random Space Modulation"

    Acoustical Physics

    40
    1
    111-115

1991

  1. V.A. Khokhlova, O.V. Rudenko
    "Kinetics of one-dimensional sawtooth waves"

    Sov. Phys. Acoust

    37
    1
    90-93
  2. I.I. Ivanchik, V.A. Khokhlova
    "Transformation of the two-point distribution functions of the parameters of a sound field in a nonlinear medium"

    Sov. Phys. Acoust

    37
    4
    369-372

1989

  1. V.A. Khokhlova, O.V. Rudenko
    "The kinetic equation of the one-dimensional acoustical turbulence"

    Vestn. Mosk. Univ.3 , Fiz. Astron.(USSR)

    30
    64-69

1988

  1. O.V. Rudenko, V.A. Khokhlova
    "Kinetic approach to the description of one-dimensional acoustical turbulence"

    Sov. Phys. Acoust. (USA)

    34
    289-292

1987

  1. O.V. Rudenko, V.A. Khokhlova
    "The statistical characteristics of high intensity diffracting acoustical noise"

    Mosc. Univ. Phys. Bull. (USA)

    42
    59-63
  2. O.V. Rudenko, V.A. Khokhlova
    "On nonlinear and diffraction effects in the sound beams with the random cross structure"

    Sov. Phys. Acoust. (USA)

    33
    195-199

1986

  1. O.V. Rudenko, V.A. Khokhlova
    "Calculation of the statistical characteristics of diffracting high intensity acoustical noise"

    Mosc. Univ. Phys. Bull. (USA)

    41
    5
    37-42

1985

  1. V.G. Andreev, O.V. Rudenko, V.A. Khokhlova, O.A. Sapozhnikov
    "Suppression of nonlinear damping of a sound wave in a medium which contains a resonant absorber with a finite line width"

    Mosc. Univ. Phys. Bull. (USA)

    40
    67-71