High-intensity focused ultrasound (HIFU) in therapy and noninvasive surgery

- modeling and measurement of nonlinear fields generated by ultrasound medical sources

- mechansms of ultrasound action on biological tissues

- High-power multi-element phased arrays for ultrasound surgery applications

Publications

Ref. Articles

  1. P.B. Rosnitskiy, P.V. Yuldashev, V.A. Khokhlova
    "Determination of the parameters of a high power ultrasound transducer to provide certain shock amplitude at the focus"

    Memoirs of the Faculty of Physics

    5
    145314
  2. P.V. Yuldashev, A. Maxwell, W. Kreider, O.A. Sapozhnikov, M. Bailey, L. Crum, V.A. Khokhlova
    "Measurement and modeling of acoustic field of a therapeutic multielement transducer in a wide range of acoustic intensities up to appearance of saturation effect in the focus"

    Memoirs of the Faculty of Physics

    5
    145346
  3. P. V. Yuldashev and V. A. Khokhlova
    "Simulation of three dimensional nonlinear fields of ultrasound therapeutic arrays"

    Acoustical Physics

    57
    3
    334–343
  4. A.D. Maxwell, B.W. Cunitz, W. Kreider, O.A. Sapozhnikov, R.S. Hsi, J.D. Harper, M.R. Bailey, M.D. Sorensen
    "Fragmentation of urinary calculi in vitro by burst wave lithotripsy"

    Journal of Urology

    193
    1
    338-344
  5. Y.-N. Wang, T.D. Khokhlova, S.V. Buravkov, V.P. Chernikov, W. Kreider, A. Partanen, N. Farr, A.D. Maxwell, G.R. Schade, V.A. Khokhlova
    "Mechanical decellularization of tissue volumes using boiling histotripsy"

    Phys. Med. Biol.

    63
    23
    235023
  6. V.A. Khokhlova, J.B. Fowlkes, W.W. Roberts, G.R. Schade, Z. Xu, T.D. Khokhlova, T.L. Hall, A.D. Maxwell, Y.N. Wang, C.A. Cain
    "Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications"

    Int. J. Hyperthermia

    31
    2
    145-162
  7. P.B. Rosnitskiy, P.V. Yuldashev, O.A. Sapozhnikov, L.R. Gavrilov, V.A. Khokhlova
    "Simulation of nonlinear trans-skull focusing and formation of shocks in brain using a fully populated ultrasound array with aberration correction"
    146
    3
    1786–1798
  8. J.C. Simon, O.A. Sapozhnikov, Y.N. Wang, V.A. Khokhlova, L.A. Crum, M.R. Bailey
    "Investigation into the mechanisms of tissue atomization by high intensity focused ultrasound"

    Ultrasound in Medicine & Biology

    41
    5
    1372-1385
  9. Y.S. Andriyakhina, M.M. Karzova, P.V. Yuldashev, V.A. Khokhlova
    "Accelerated thermal ablation of biological tissue volumes using HIFU beams with shock fronts"

    Acoustical Physics

    65
    2
    141-150
  10. W. Kreider, P. V. Yuldashev, O. A. Sapozhnikov, N. Farr, A. Partanen, M. R. Bailey, and V. A. Khokhlova
    "Characterization of a Multi-Element Clinical HIFU System Using Acoustic Holography and Nonlinear Modeling"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

    60
    8
    1683-1698
  11. О.A. Sapozhnikov, S.A. Tsysar, V.A. Khokhlova, W. Kreider
    "Acoustic holography as a metrological tool for characterizing medical ultrasound sources and fields"

    The Journal of the Acoustical Society of America

    138
    3
    1515-1532
  12. A.V. Nikolaeva, M.M. Karzova, S.A. Tsysar, V.A. Khokhlova, O.A. Sapozhnikov
    "Simulating and measuring the acoustic radiation force of a focused ultrasonic beam on elastic spheres in water"

    Bulletin of the Russian Academy of Sciences: Physics

    83
    1
    77-81
  13. V. A. Khokhlova, S. M. Shmeleva, L. R. Gavrilov, E. Martin, N. Sadhoo, and A. Shaw
    "Infrared mapping of ultrasound fields generated by medical transducers: Feasibility of determining absolute intensity levels"

    J. Acoust. Soc. Am.

    134
    2
    1586–1597
  14. A.N. Rybyanets, A.A. Naumenko, O.A. Sapozhnikov, V.A. Khokhlova
    "New methods and transducer designs for ultrasonic diagnostics and therapy"

    Physics procedia

    70
    1152-1156
  15. E.A Annenkova, O.A. Sapozhnikov
    "Surface instability and thermal and cavitational phenomena as mechanisms of drop explosions in acoustic fountains"

    Bulletin of the Russian Academy of Sciences: Physics

    83
    1
    73-76
  16. T. D. Khokhlova, Y.-N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova
    "Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model"

    PNAS

    111
    22
    8161-8166
  17. Gavrilov L.R., Sapozhnikov O.A., Khokhlova V.A.
    "Spiral arrangement of elements of two-dimensional ultrasonic therapeutic arrays as a way of increasing the intensity at the focus"

    Bulletin of the Russian Academy of Sciences. Physics

    79
    10
    1232–1237
  18. V.A. Khokhlova, P.B. Rosnitskiy, S.A. Tsysar, S.V. Buravkov, O.A. Sapozhnikov, M.M. Karzova, T.D. Khokhlova, A.D. Maxwell, N.M. Gaifullin, A.V. Kadrev, D.A. Okhobotov, A.A. Kamalov, G.R. Schade
    "A novel method for non-invasive mechanical ablation of prostate tumors using pulsed focused ultrasound"

    Urologiia

    6
    67-73 (in Russian)
  19. E. G. Lobanova, S. V. Lobanov, and V. A. Khokhlova
    "Counterpropagation of Waves with Shock Fronts in a Nonlinear TissueLike Medium"

    Acoustical Physics, 2014

    60
    4
    387–397
  20. J. C. Simon, O. A. Sapozhnikov, V. A. Khokhlova, L. A. Crum and M. R. Bailey
    "Ultrasonic atomization of liquids in drop-chain acoustic fountains"

    J. Fluid Mech. (2015)

    766
    129-146
  21. Vera A. Khokhlova, J. Brian Fowlkes, William W. Roberts, George R. Schade, Zhen Xu, Tatiana D. Khokhlova,Timothy L. Hall, Adam D. Maxwell, Yak-Nam Wang, & Charles A. Cain
    "Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications"

    Int J Hyperthermia, 2015

    31
    2
    145-162
  22. P. B. Rosnitskiy, P. V. Yuldashev, and V. A. Khokhlova
    "Effect of the Angular Aperture of Medical Ultrasound Transducers on the Parameters of Nonlinear Ultrasound Field with Shocks at the Focus"

    Acoustical Physics, 2015

    61
    3
    301-307
  23. M.M. Karzova, M.V. Averiyanov, O.A. Sapozhnikov, and V.A. Khokhlova
    "Mechanisms for saturation of nonlinear pulsed and periodic signals in focused acoustic beams"

    Acoust. Phys.

    58
    1
    81–89
  24. V. A. Khokhlova, Y.-N. Wang, S.V. Buravkov, A.D. Maxwell, T.D. Khokhlova, D.W. Lin, O.A. Sapozhnikov, M.R. Bailey, G.R. Schade
    "Histological analysis of mechanical lesions induced by high intensity focused ultrasound in ex-vivo human and porcine kidneys"

    Memoirs of the Faculty of Physics

    5
    145343
  25. S.A. Ilyin, L.R. Gavrilov, V.A. Khokhlova
    "Application of ultrasound phased arrays with different number of elements for irradiation of tissue behind the ribs"

    Memoirs of the Faculty of Physics

    5
    145342

Abstracts

  1. P.B. Rosnitskiy, S.A. Ilyin, O.A. Sapozhnikov, L.R. Gavrilov, P.V. Yuldashev, V.A. Khokhova
    "T-ARRAY: a software package for fast simulation of therapeutic ultrasound fields radiated by multi-element phased arrays"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    424-426
  2. T. Looi, V. Khokhlova, C. Mougenot, K. Hynynen, J. Drake
    "In vivo feasibiltiy study of boiling histotripsy with clinical sonalleve system in a neurological porcine model"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    64-66
  3. T.D. Khokhlova, G.R. Schade, Y.-N. Wang, W. Kreider, J. Simon, F. Starr, M.M. Karzova, A. Maxwell, M.R. Bailey, V.A. Khokhlova
    "Feasibility of transcutaneous volumetric boiling histotripsy ablation of liver and kidney in a pig model"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    274-276
  4. G.R. Schade, Y.-N. Wang, T.D. Khokhlova, P. May, D.W. Lin, M.R. Bailey, V.A. Khokhlova
    " Assessment of boiling histotripsy dose in human ex vivo kidneys and renal tumours"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    280-281
  5. O.A. Sapozhnikov, S.A. Tsysar, P.V. Yuldashev, V.A. Khokhlova, V.D. Svet, W. Kreider
    "Two-dimensional array synthesis using raster-scanned singlehydrophone in application to acoustic holography and ultrasound imaging"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    313-315
  6. P.V. Yuldashev, M.M. Karzova, B.W. Cunitz, B. Dunmire, W. Kreider, O.A. Sapozhnikov, M.R. Bailey, V.A. Khokhlova
    "Comparison of derating methods for nonlinear ultrasound fields of diagnostic-type transducers"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    318-321
  7. V. Khokhlova, P. Yuldashev, I. Sinilshchikov, Y. Andriyakhina, W. Kreider, A. Maxwell, T. Khokhlova, O. Sapozhnikov, A. Partanen
    "Acceleration of thermal ablation of tissue volumes in high intensity focused ultrasound therapy using shock wave exposures"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    339-342
  8. A. Rybyanets, N. Shvetsova, A. Berkovich, I. Shvetsov, O. Sapozhnikov, V. Khokhlova
    "Ultrasonic hemostatsis of deep arterial bleeding"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    343-345

Books

  1. L.R. Gavrilov, J.W. Hand
    "High-Power Ultrasound Phased Arrays for Medical Applications"

    (The manuscript of the book, prepared for publication by Nova Science Publishers. Submitted May 9, 2014; published August 20, 2014)

  2. L.R. Gavrilov
    "Use of Focused Ultrasound for Stimulation of Various Neural Structures"

    (The manuscript of the book, prepared for publication by Nova Science Publishers. Submitted December 15, 2013, published February 15, 2014)