High-intensity focused ultrasound (HIFU) in therapy and noninvasive surgery

- modeling and measurement of nonlinear fields generated by ultrasound medical sources

- mechansms of ultrasound action on biological tissues

- High-power multi-element phased arrays for ultrasound surgery applications

Publications

Ref. Articles

  1. V.A. Khokhlova, J.B. Fowlkes, W.W. Roberts, G.R. Schade, Z. Xu, T.D. Khokhlova, T.L. Hall, A.D. Maxwell, Y.N. Wang, C.A. Cain
    "Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications"

    Int. J. Hyperthermia

    31
    2
    145-162
    PDF icon download
  2. P.B. Rosnitskiy, P.V. Yuldashev, O.A. Sapozhnikov, L.R. Gavrilov, V.A. Khokhlova
    "Simulation of nonlinear trans-skull focusing and formation of shocks in brain using a fully populated ultrasound array with aberration correction"

    The Journal of the Acoustical Society of America

    146
    3
    1786–1798
    PDF icon download
  3. J.C. Simon, O.A. Sapozhnikov, Y.N. Wang, V.A. Khokhlova, L.A. Crum, M.R. Bailey
    "Investigation into the mechanisms of tissue atomization by high intensity focused ultrasound"

    Ultrasound in Medicine & Biology

    41
    5
    1372-1385
    PDF icon download
  4. Y.S. Andriyakhina, M.M. Karzova, P.V. Yuldashev, V.A. Khokhlova
    "Accelerated thermal ablation of biological tissue volumes using HIFU beams with shock fronts"

    Acoustical Physics

    65
    2
    141-150
    PDF icon download
  5. W. Kreider, P. V. Yuldashev, O. A. Sapozhnikov, N. Farr, A. Partanen, M. R. Bailey, and V. A. Khokhlova
    "Characterization of a Multi-Element Clinical HIFU System Using Acoustic Holography and Nonlinear Modeling"

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

    60
    8
    1683-1698
    PDF icon download
  6. О.A. Sapozhnikov, S.A. Tsysar, V.A. Khokhlova, W. Kreider
    "Acoustic holography as a metrological tool for characterizing medical ultrasound sources and fields"

    The Journal of the Acoustical Society of America

    138
    3
    1515-1532
    PDF icon download
  7. A.V. Nikolaeva, M.M. Karzova, S.A. Tsysar, V.A. Khokhlova, O.A. Sapozhnikov
    "Simulating and measuring the acoustic radiation force of a focused ultrasonic beam on elastic spheres in water"

    Bulletin of the Russian Academy of Sciences: Physics

    83
    1
    77-81
    PDF icon download
  8. V. A. Khokhlova, S. M. Shmeleva, L. R. Gavrilov, E. Martin, N. Sadhoo, and A. Shaw
    "Infrared mapping of ultrasound fields generated by medical transducers: Feasibility of determining absolute intensity levels"

    J. Acoust. Soc. Am.

    134
    2
    1586–1597
    PDF icon download
  9. A.N. Rybyanets, A.A. Naumenko, O.A. Sapozhnikov, V.A. Khokhlova
    "New methods and transducer designs for ultrasonic diagnostics and therapy"

    Physics procedia

    70
    1152-1156
    PDF icon download
  10. E.A Annenkova, O.A. Sapozhnikov
    "Surface instability and thermal and cavitational phenomena as mechanisms of drop explosions in acoustic fountains"

    Bulletin of the Russian Academy of Sciences: Physics

    83
    1
    73-76
    PDF icon download
  11. T. D. Khokhlova, Y.-N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova
    "Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model"

    PNAS

    111
    22
    8161-8166
    PDF icon download
  12. Gavrilov L.R., Sapozhnikov O.A., Khokhlova V.A.
    "Spiral arrangement of elements of two-dimensional ultrasonic therapeutic arrays as a way of increasing the intensity at the focus"

    Bulletin of the Russian Academy of Sciences. Physics

    79
    10
    1232–1237
    PDF icon download
  13. V.A. Khokhlova, P.B. Rosnitskiy, S.A. Tsysar, S.V. Buravkov, O.A. Sapozhnikov, M.M. Karzova, T.D. Khokhlova, A.D. Maxwell, N.M. Gaifullin, A.V. Kadrev, D.A. Okhobotov, A.A. Kamalov, G.R. Schade
    "A novel method for non-invasive mechanical ablation of prostate tumors using pulsed focused ultrasound"

    Urologiia

    6
    67-73 (in Russian)
    PDF icon download
  14. E. G. Lobanova, S. V. Lobanov, and V. A. Khokhlova
    "Counterpropagation of Waves with Shock Fronts in a Nonlinear TissueLike Medium"

    Acoustical Physics, 2014

    60
    4
    387–397
    PDF icon download
  15. J. C. Simon, O. A. Sapozhnikov, V. A. Khokhlova, L. A. Crum and M. R. Bailey
    "Ultrasonic atomization of liquids in drop-chain acoustic fountains"

    J. Fluid Mech. (2015)

    766
    129-146
    PDF icon download
  16. Vera A. Khokhlova, J. Brian Fowlkes, William W. Roberts, George R. Schade, Zhen Xu, Tatiana D. Khokhlova,Timothy L. Hall, Adam D. Maxwell, Yak-Nam Wang, & Charles A. Cain
    "Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications"

    Int J Hyperthermia, 2015

    31
    2
    145-162
    PDF icon download
  17. P. B. Rosnitskiy, P. V. Yuldashev, and V. A. Khokhlova
    "Effect of the Angular Aperture of Medical Ultrasound Transducers on the Parameters of Nonlinear Ultrasound Field with Shocks at the Focus"

    Acoustical Physics, 2015

    61
    3
    301-307
    PDF icon download
  18. M.M. Karzova, M.V. Averiyanov, O.A. Sapozhnikov, and V.A. Khokhlova
    "Mechanisms for saturation of nonlinear pulsed and periodic signals in focused acoustic beams"

    Acoust. Phys.

    58
    1
    81–89
    PDF icon download
  19. V. A. Khokhlova, Y.-N. Wang, S.V. Buravkov, A.D. Maxwell, T.D. Khokhlova, D.W. Lin, O.A. Sapozhnikov, M.R. Bailey, G.R. Schade
    "Histological analysis of mechanical lesions induced by high intensity focused ultrasound in ex-vivo human and porcine kidneys"

    Memoirs of the Faculty of Physics

    5
    145343
  20. S.A. Ilyin, L.R. Gavrilov, V.A. Khokhlova
    "Application of ultrasound phased arrays with different number of elements for irradiation of tissue behind the ribs"

    Memoirs of the Faculty of Physics

    5
    145342
  21. P.B. Rosnitskiy, P.V. Yuldashev, V.A. Khokhlova
    "Determination of the parameters of a high power ultrasound transducer to provide certain shock amplitude at the focus"

    Memoirs of the Faculty of Physics

    5
    145314
  22. P.V. Yuldashev, A. Maxwell, W. Kreider, O.A. Sapozhnikov, M. Bailey, L. Crum, V.A. Khokhlova
    "Measurement and modeling of acoustic field of a therapeutic multielement transducer in a wide range of acoustic intensities up to appearance of saturation effect in the focus"

    Memoirs of the Faculty of Physics

    5
    145346
  23. P. V. Yuldashev and V. A. Khokhlova
    "Simulation of three dimensional nonlinear fields of ultrasound therapeutic arrays"

    Acoustical Physics

    57
    3
    334–343
    PDF icon download
  24. A.D. Maxwell, B.W. Cunitz, W. Kreider, O.A. Sapozhnikov, R.S. Hsi, J.D. Harper, M.R. Bailey, M.D. Sorensen
    "Fragmentation of urinary calculi in vitro by burst wave lithotripsy"

    Journal of Urology

    193
    1
    338-344
    PDF icon download
  25. Y.-N. Wang, T.D. Khokhlova, S.V. Buravkov, V.P. Chernikov, W. Kreider, A. Partanen, N. Farr, A.D. Maxwell, G.R. Schade, V.A. Khokhlova
    "Mechanical decellularization of tissue volumes using boiling histotripsy"

    Phys. Med. Biol.

    63
    23
    235023

Abstracts

  1. T. Looi, V. Khokhlova, C. Mougenot, K. Hynynen, J. Drake
    "In vivo feasibiltiy study of boiling histotripsy with clinical sonalleve system in a neurological porcine model"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    64-66
    PDF icon download
  2. T.D. Khokhlova, G.R. Schade, Y.-N. Wang, W. Kreider, J. Simon, F. Starr, M.M. Karzova, A. Maxwell, M.R. Bailey, V.A. Khokhlova
    "Feasibility of transcutaneous volumetric boiling histotripsy ablation of liver and kidney in a pig model"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    274-276
    PDF icon download
  3. G.R. Schade, Y.-N. Wang, T.D. Khokhlova, P. May, D.W. Lin, M.R. Bailey, V.A. Khokhlova
    " Assessment of boiling histotripsy dose in human ex vivo kidneys and renal tumours"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    280-281
    PDF icon download
  4. O.A. Sapozhnikov, S.A. Tsysar, P.V. Yuldashev, V.A. Khokhlova, V.D. Svet, W. Kreider
    "Two-dimensional array synthesis using raster-scanned singlehydrophone in application to acoustic holography and ultrasound imaging"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    313-315
    PDF icon download
  5. P.V. Yuldashev, M.M. Karzova, B.W. Cunitz, B. Dunmire, W. Kreider, O.A. Sapozhnikov, M.R. Bailey, V.A. Khokhlova
    "Comparison of derating methods for nonlinear ultrasound fields of diagnostic-type transducers"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    318-321
    PDF icon download
  6. V. Khokhlova, P. Yuldashev, I. Sinilshchikov, Y. Andriyakhina, W. Kreider, A. Maxwell, T. Khokhlova, O. Sapozhnikov, A. Partanen
    "Acceleration of thermal ablation of tissue volumes in high intensity focused ultrasound therapy using shock wave exposures"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    339-342
    PDF icon download
  7. A. Rybyanets, N. Shvetsova, A. Berkovich, I. Shvetsov, O. Sapozhnikov, V. Khokhlova
    "Ultrasonic hemostatsis of deep arterial bleeding"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    343-345
    PDF icon download
  8. P.B. Rosnitskiy, S.A. Ilyin, O.A. Sapozhnikov, L.R. Gavrilov, P.V. Yuldashev, V.A. Khokhova
    "T-ARRAY: a software package for fast simulation of therapeutic ultrasound fields radiated by multi-element phased arrays"

    Program Booklet of the 16th International Symposium on Therapeutic Ultrasound (March 14 - 16, 2016, Tel Aviv, Israel)

    424-426
    PDF icon download

Books

  1. L.R. Gavrilov, J.W. Hand
    "High-Power Ultrasound Phased Arrays for Medical Applications"

    (The manuscript of the book, prepared for publication by Nova Science Publishers. Submitted May 9, 2014; published August 20, 2014)

    PDF icon download
  2. L.R. Gavrilov
    "Use of Focused Ultrasound for Stimulation of Various Neural Structures"

    (The manuscript of the book, prepared for publication by Nova Science Publishers. Submitted December 15, 2013, published February 15, 2014)

    PDF icon download